Glycylcyclines: a new generation of tetracyclines
نویسندگان
چکیده
منابع مشابه
Glycylcyclines: a new generation of tetracyclines.
The widespread dissemination of genes encoding tetracycline resistance has limited the utility of the tetracyclines for many clinical indications (Chopra, Hawkey & Hilton, 1992). There are three types of tetracycline resistance mechanisms described (Speer, Shoemaker & Salyers, 1992): 1) efflux, mediated by trans-membrane-spanning proteins, which results in reduction of the intracellular tetracy...
متن کاملPharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.
The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, repr...
متن کاملInhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines.
One of the two major mechanisms of tetracycline resistance is ribosomal protection. Of this resistance type, tet(M) is the best characterized. Although the mechanism of tet(M) resistance has not yet been fully elucidated, it has been demonstrated that ribosomes isolated from a tet(M) strain are resistant to inhibition of protein synthesis by tetracycline. A new generation of tetracycline compou...
متن کاملNanobody as a new generation of functional proteins
Nanobody (Nb) or VHH is the smallest binding domain of camelid heavy chain antibody (HcAb). Light chains of HcAb naturally removed and because of some evolutionary changes, Nbs have unique properties rather than conventional antibodies. The size of Nb is about one-tenth (0.1) of whole antibodies and this size improved some problems of four chains antibodies such as high yield of expression in p...
متن کاملA NEW GENERATION OF OXYNITRIDE GLASSES CONTAINING FLUORINE
Oxynitride glasses are found as grain boundary phases in silicon nitride ceramics. They are effectively alumino-silicate glasses in which nitrogen substitutes for oxygen in the glass network, and this causes increases in glass transition and softening temperatures, viscosities (by two to three orders of magnitude), elastic moduli and microhardness. Calcium silicate-based glasses containing fluo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1995
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/35.4.449